Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry

Overview

Education:

Ph.D., Yale University 2000

Mustoe, AM, Brooks, CL, and Al-Hashimi, HM. "Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity." Nucleic acids research 42.18 (October 2014): 11792-11804. Full Text

Alvey, HS, Gottardo, FL, Nikolova, EN, and Al-Hashimi, HM. "Widespread transient Hoogsteen base pairs in canonical duplex DNA with variable energetics." Nature communications 5 (September 4, 2014): 4786-. Full Text

Sathyamoorthy, B, Lee, J, Kimsey, I, Ganser, LR, and Al-Hashimi, H. "Development and application of aromatic [13C, 1H] SOFAST-HMQC NMR experiment for nucleic acids." Journal of Biomolecular NMR 60.2-3 (September 4, 2014): 77-83. Full Text

Zeng, X, Chugh, J, Casiano-Negroni, A, Al-Hashimi, HM, and Brooks, CL. "Flipping of the ribosomal A-site adenines provides a basis for tRNA selection." Journal of molecular biology 426.19 (September 2014): 3201-3213. Full Text

Horowitz, S, Adhikari, U, Dirk, LMA, Del Rizzo, PA, Mehl, RA, Houtz, RL, Al-Hashimi, HM, Scheiner, S, and Trievel, RC. "Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis." ACS chemical biology 9.8 (August 2014): 1692-1697. Full Text

Ganser, LR, Mustoe, AM, and Al-Hashimi, HM. "An RNA tertiary switch by modifying how helices are tethered." Genome biology 15.7 (July 30, 2014): 425-. Full Text

Lee, J, Dethoff, EA, and Al-Hashimi, HM. "Invisible RNA state dynamically couples distant motifs." Proceedings of the National Academy of Sciences of the United States of America 111.26 (July 2014): 9485-9490. Full Text

Bothe, JR, Stein, ZW, and Al-Hashimi, HM. "Evaluating the uncertainty in exchange parameters determined from off-resonance R1ρ relaxation dispersion for systems in fast exchange." Journal of magnetic resonance (San Diego, Calif. : 1997) 244 (July 2014): 18-29. Full Text

Zeng, X, Chugh, J, Casiano-Negroni, A, Al-Hashimi, HM, and Brooks, CL. "Flipping of the Ribosomal A-Site Adenines Provides a Basis for tRNA Selection (Accepted)." Journal of Molecular Biology (June 10, 2014). Full Text

Eichhorn, CD, and Al-Hashimi, HM. "Structural dynamics of a single-stranded RNA-helix junction using NMR." RNA (New York, N.Y.) 20.6 (June 2014): 782-791. Full Text

Pages