Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry

Overview

Education:

Ph.D., Yale University 2000

Zhou, H, Hintze, BJ, Kimsey, IJ, Sathyamoorthy, B, Yang, S, Richardson, JS, and Al-Hashimi, HM. "New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey." Nucleic acids research 43.7 (April 2015): 3420-3433. (Review) Full Text Open Access Copy

Kimsey, IJ, Petzold, K, Sathyamoorthy, B, Stein, ZW, and Al-Hashimi, HM. "Visualizing transient Watson-Crick-like mispairs in DNA and RNA duplexes." Nature 519.7543 (March 11, 2015): 315-320. Full Text

Mustoe, AM, Liu, X, Lin, PJ, Al-Hashimi, HM, Fierke, CA, and Brooks, CL. "Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding." Journal of the American Chemical Society 137.10 (March 9, 2015): 3592-3599. Full Text

Mouzakis, KD, Dethoff, EA, Tonelli, M, Al-Hashimi, H, and Butcher, SE. "Dynamic motions of the HIV-1 frameshift site RNA." Biophysical journal 108.3 (February 2015): 644-654. Full Text

Allain, FH-T, and Al-Hashimi, HM. "Editorial overview: Nucleic acids and their protein complexes: Progress in nucleic acid structural biology: new technologies and discoveries." Current opinion in structural biology 30 (February 2015): vii-viii. Full Text

Xue, Y, Kellogg, D, Kimsey, IJ, Sathyamoorthy, B, Stein, ZW, McBrairty, M, and Al-Hashimi, HM. "Characterizing RNA excited states using NMR relaxation dispersion." Methods in Enzymology 558.1 (January 1, 2015): 39-73. Full Text

Xue, Y, Kellogg, D, Kimsey, IJ, Sathyamoorthy, B, Stein, ZW, McBrairty, M, and Al-Hashimi, HM. "Characterizing RNA Excited States Using NMR Relaxation Dispersion." Methods in enzymology 558 (January 2015): 39-73. Full Text

Nikolova, EN, Stull, F, and Al-Hashimi, HM. "Guanine to inosine substitution leads to large increases in the population of a transient G·C Hoogsteen base pair." Biochemistry 53.46 (November 10, 2014): 7145-7147. Full Text

Sathyamoorthy, B, Lee, J, Kimsey, I, Ganser, LR, and Al-Hashimi, H. "Development and application of aromatic [(13)C, (1)H] SOFAST-HMQC NMR experiment for nucleic acids." Journal of biomolecular NMR 60.2-3 (November 2014): 77-83. Full Text

Ravera, E, Salmon, L, Fragai, M, Parigi, G, Al-Hashimi, H, and Luchinat, C. "Insights into domain-domain motions in proteins and RNA from solution NMR." Accounts of chemical research 47.10 (October 2014): 3118-3126. (Review) Full Text

Pages