Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry



Ph.D., Yale University 2000

Zhou, H, Kimsey, IJ, Nikolova, EN, Sathyamoorthy, B, Grazioli, G, McSally, J, Bai, T, Wunderlich, CH, Kreutz, C, Andricioaei, I, and Al-Hashimi, HM. "m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs." Nature structural & molecular biology 23.9 (September 2016): 803-810. Full Text

Merriman, DK, Xue, Y, Yang, S, Kimsey, IJ, Shakya, A, Clay, M, and Al-Hashimi, HM. "Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes over a Broad Range of Time Scales." Biochemistry 55.32 (August 2016): 4445-4456. Full Text

Xue, Y, Gracia, B, Herschlag, D, Russell, R, and Al-Hashimi, HM. "Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch." Nature communications 7 (June 13, 2016): ncomms11768-. Full Text

Andrałojć, W, Ravera, E, Salmon, L, Parigi, G, Al-Hashimi, HM, and Luchinat, C. "Inter-helical conformational preferences of HIV-1 TAR-RNA from maximum occurrence analysis of NMR data and molecular dynamics simulations." Physical chemistry chemical physics : PCCP 18.8 (February 2016): 5743-5752. Full Text

Shakya, A, Dougherty, CA, Xue, Y, Al-Hashimi, HM, and Banaszak Holl, MM. "Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release." Biomacromolecules 17.1 (January 2016): 154-164. Full Text

Mustoe, AM, Al-Hashimi, HM, and Brooks, CL. "Secondary structure encodes a cooperative tertiary folding funnel in the Azoarcus ribozyme." Nucleic acids research 44.1 (January 2016): 402-412. Full Text

Ren, A, Xue, Y, Peselis, A, Serganov, A, Al-Hashimi, HM, and Patel, DJ. "Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch." Cell reports 13.9 (December 2015): 1800-1813. Full Text

Swanson, MD, Boudreaux, DM, Salmon, L, Chugh, J, Winter, HC, Meagher, JL, André, S, Murphy, PV, Oscarson, S, Roy, R, King, S, Kaplan, MH, Goldstein, IJ, Tarbet, EB, Hurst, BL, Smee, DF, de la Fuente, C, Hoffmann, H-H, Xue, Y, Rice, CM, Schols, D, Garcia, JV, Stuckey, JA, Gabius, H-J, Al-Hashimi, HM, and Markovitz, DM. "Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity." Cell 163.3 (October 22, 2015): 746-758. Full Text

Salmon, L, Giambaşu, GM, Nikolova, EN, Petzold, K, Bhattacharya, A, Case, DA, and Al-Hashimi, HM. "Modulating RNA Alignment Using Directional Dynamic Kinks: Application in Determining an Atomic-Resolution Ensemble for a Hairpin using NMR Residual Dipolar Couplings." Journal of the American Chemical Society 137.40 (October 2015): 12954-12965. Full Text