Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry

Overview

Education:

Ph.D., Yale University 2000

Ganser, LR, and Al-Hashimi, HM. "HIV-1 leader RNA dimeric interface revealed by NMR." Proceedings of the National Academy of Sciences of the United States of America 113.47 (November 11, 2016): 13263-13265. Full Text

Shakya, A, Al-Hashimi, HM, and Banaszak Holl, MM. "Three RNA Microenvironments Detected in Fluxional Gene Delivery Polyplex Nanoassemblies." ACS Macro Letters 5.10 (October 18, 2016): 1104-1108. Full Text

Gracia, B, Xue, Y, Bisaria, N, Herschlag, D, Al-Hashimi, HM, and Russell, R. "RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly." Journal of molecular biology 428.20 (October 2016): 3972-3985. Full Text

Zhou, H, Kimsey, IJ, Nikolova, EN, Sathyamoorthy, B, Grazioli, G, McSally, J, Bai, T, Wunderlich, CH, Kreutz, C, Andricioaei, I, and Al-Hashimi, HM. "m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs." Nature structural & molecular biology 23.9 (September 2016): 803-810. Full Text

Merriman, DK, Xue, Y, Yang, S, Kimsey, IJ, Shakya, A, Clay, M, and Al-Hashimi, HM. "Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes over a Broad Range of Time Scales." Biochemistry 55.32 (August 2016): 4445-4456. Full Text

Xue, Y, Gracia, B, Herschlag, D, Russell, R, and Al-Hashimi, HM. "Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch." Nature communications 7 (June 13, 2016): ncomms11768-. Full Text

Andrałojć, W, Ravera, E, Salmon, L, Parigi, G, Al-Hashimi, HM, and Luchinat, C. "Inter-helical conformational preferences of HIV-1 TAR-RNA from maximum occurrence analysis of NMR data and molecular dynamics simulations." Physical chemistry chemical physics : PCCP 18.8 (February 2016): 5743-5752. Full Text

Mustoe, AM, Al-Hashimi, HM, and Brooks, CL. "Secondary structure encodes a cooperative tertiary folding funnel in the Azoarcus ribozyme." Nucleic acids research 44.1 (January 2016): 402-412. Full Text

Shakya, A, Dougherty, CA, Xue, Y, Al-Hashimi, HM, and Banaszak Holl, MM. "Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release." Biomacromolecules 17.1 (January 2016): 154-164. Full Text

Ren, A, Xue, Y, Peselis, A, Serganov, A, Al-Hashimi, HM, and Patel, DJ. "Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch." Cell reports 13.9 (December 2015): 1800-1813. Full Text

Pages

Goh, GB, Nikolova, EN, Al-Hashimi, H, and Brooks, CL. "Elucidating transient protonated GC(+) Hoogstein base pairs in canonical DNA duplexes." April 7, 2013.