Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry



Ph.D., Yale University 2000

Gracia, B, Al-Hashimi, HM, Bisaria, N, Das, R, Herschlag, D, and Russell, R. "Hidden Structural Modules in a Cooperative RNA Folding Transition." Cell reports 22.12 (March 2018): 3240-3250. Full Text

Kimsey, IJ, Szymanski, ES, Zahurancik, WJ, Shakya, A, Xue, Y, Chu, C-C, Sathyamoorthy, B, Suo, Z, and Al-Hashimi, HM. "Dynamic basis for dG•dT misincorporation via tautomerization and ionization." Nature 554.7691 (February 2018): 195-201. Full Text

Salmon, L, Stull, F, Sayle, S, Cato, C, Akgül, Ş, Foit, L, Ahlstrom, LS, Eisenmesser, EZ, Al-Hashimi, HM, Bardwell, JCA, and Horowitz, S. "The Mechanism of HdeA Unfolding and Chaperone Activation." Journal of molecular biology 430.1 (January 2018): 33-40. Full Text

Clay, MC, Ganser, LR, Merriman, DK, and Al-Hashimi, HM. "Resolving sugar puckers in RNA excited states exposes slow modes of repuckering dynamics." Nucleic acids research 45.14 (August 2017): e134-. Full Text

Stelling, AL, Xu, Y, Zhou, H, Choi, SH, Clay, MC, Merriman, DK, and Al-Hashimi, HM. "Robust IR-based detection of stable and fractionally populated G-C+ and A-T Hoogsteen base pairs in duplex DNA." FEBS letters 591.12 (June 2017): 1770-1784. Full Text

Vaidyanathan, PP, AlSadhan, I, Merriman, DK, Al-Hashimi, HM, and Herschlag, D. "Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions." RNA 23.5 (May 2017): 611-618. Full Text

Patwardhan, NN, Ganser, LR, Kapral, GJ, Eubanks, CS, Lee, J, Sathyamoorthy, B, Al-Hashimi, HM, and Hargrove, AE. "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR." MedChemComm 8.5 (May 2017): 1022-1036. Full Text

Sathyamoorthy, B, Shi, H, Zhou, H, Xue, Y, Rangadurai, A, Merriman, DK, and Al-Hashimi, HM. "Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A." Nucleic acids research 45.9 (May 2017): 5586-5601. Full Text

Szymanski, ES, Kimsey, IJ, and Al-Hashimi, HM. "Direct NMR Evidence that Transient Tautomeric and Anionic States in dG·dT Form Watson-Crick-like Base Pairs." Journal of the American Chemical Society 139.12 (March 14, 2017): 4326-4329. Full Text

Ganser, LR, and Al-Hashimi, HM. "HIV-1 leader RNA dimeric interface revealed by NMR." Proceedings of the National Academy of Sciences of the United States of America 113.47 (November 11, 2016): 13263-13265. Full Text


Goh, GB, Nikolova, EN, Al-Hashimi, H, and Brooks, CL. "Elucidating transient protonated GC(+) Hoogstein base pairs in canonical DNA duplexes." April 7, 2013.