Faculty Profiles

Eric John Toone
Professor of Chemistry
Office: 
215 Morris Street, Suite 300, Durham, NC 27708
Phone: 
(919) 681-3484
Fax: 
(919) 660-1591

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Gao, W, Liu, W, Mackay, JA, Zalutsky, MR, Toone, EJ, and Chilkoti, A. "In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics." Proc Natl Acad Sci U S A 106.36 (September 8, 2009): 15231-15236. Full Text

Arnold, JJ, Choksi, Y, Chen, X, Shimazaki, A, Hatten, J, Toone, EJ, Epstein, DL, and Challa, P. "Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits." J Ocul Pharmacol Ther 25.3 (June 2009): 179-186. Full Text

Chakrapani, H, Bartberger, MD, and Toone, EJ. "C-nitroso donors of nitric oxide." J Org Chem 74.4 (February 20, 2009): 1450-1453. Full Text

Gavin, JW, Jon, ST, and Toone, EJ. "Natural product glycosyltransferases: Properties and applications." Advances in Enzymology and Related Areas of Molecular Biology 76 (2009): 55-119.

Rivera, M, Morris, C, Carlson, D, Toone, EJ, Cole, DG, and Clark, RL. "Minimizing tip-sample contact force in automated atomic force microscope based force spectroscopy." Proceedings of the ASME Design Engineering Technical Conference 6 (2009): 731-736. Full Text

Toone, EJ. "Advances in enzymology and related areas of molecular biology. Preface." Adv Enzymol Relat Areas Mol Biol 76 (2009): ix-x.

Lai, T-S, Liu, Y, Tucker, T, Daniel, KR, Sane, DC, Toone, E, Burke, JR, Strittmatter, WJ, and Greenberg, CS. "Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries." Chem Biol 15.9 (September 22, 2008): 969-978. Full Text

Walters, MJ, Srikannathasan, V, McEwan, AR, Naismith, JH, Fierke, CA, and Toone, EJ. "Characterization and crystal structure of Escherichia coli KDPGal aldolase." Bioorg Med Chem 16.2 (January 15, 2008): 710-720. Full Text

Shestopalov, AA, Clark, RL, and Toone, EJ. "Inkless microcontact printing on self-assembled monolayers of fmoc-protected aminothiols." J Am Chem Soc 129.45 (November 14, 2007): 13818-13819. Full Text

Cheriyan, M, Toone, EJ, and Fierke, CA. "Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates." Protein Sci 16.11 (November 2007): 2368-2377. Full Text

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