Faculty Profiles

Eric John Toone
Professor of Chemistry
Office: 
215 Morris Street, Suite 300, Durham, NC 27708
Phone: 
(919) 681-3484
Fax: 
(919) 660-1591

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Yamazaki, A, Li, J, Zeng, Q, Khokhani, D, Hutchins, WC, Yost, AC, Biddle, E, Toone, EJ, Chen, X, and Yang, C-H. "Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system." Antimicrob Agents Chemother 56.1 (January 2012): 36-43. Full Text

Bowers, CM, Toone, EJ, Clark, RL, and Shestopalov, AA. "Soft lithographic functionalization and patterning oxide-free silicon and germanium. (Published online)" J Vis Exp 58 (December 16, 2011). Full Text

Cheriyan, M, Walters, MJ, Kang, BD, Anzaldi, LL, Toone, EJ, and Fierke, CA. "Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate." Bioorg Med Chem 19.21 (November 1, 2011): 6447-6453. Full Text

Wilfong, EM, Kogiso, Y, Muthukrishnan, S, Kowatz, T, Du, Y, Bowie, A, Naismith, JH, Hadad, CM, Toone, EJ, and Gustafson, TL. "A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model." J Am Chem Soc 133.30 (August 3, 2011): 11515-11523. Full Text

Nguyen, BD, Cunningham, D, Liang, X, Chen, X, Toone, EJ, Raetz, CRH, Zhou, P, and Valdivia, RH. "Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis." Proc Natl Acad Sci U S A 108.25 (June 21, 2011): 10284-10289. Full Text

Shestopalov, AA, Morris, CJ, Vogen, BN, Hoertz, A, Clark, RL, and Toone, EJ. "Soft-lithographic approach to functionalization and nanopatterning oxide-free silicon." Langmuir 27.10 (May 17, 2011): 6478-6485. Full Text

Morris, CJ, Shestopalov, AA, Gold, BH, Clark, RL, and Toone, EJ. "Patterning NHS-terminated SAMs on germanium." Langmuir 27.10 (May 17, 2011): 6486-6489. Full Text

Hwang, S, Schmitt, AA, Luteran, AE, Toone, EJ, and McCafferty, DG. "Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST." Biochemistry 50.4 (February 1, 2011): 546-557. Full Text

Lee, C-J, Liang, X, Chen, X, Zeng, D, Joo, SH, Chung, HS, Barb, AW, Swanson, SM, Nicholas, RA, Li, Y, Toone, EJ, Raetz, CRH, and Zhou, P. "Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design." Chem Biol 18.1 (January 28, 2011): 38-47. Full Text

Liang, X, Lee, C-J, Chen, X, Chung, HS, Zeng, D, Raetz, CRH, Li, Y, Zhou, P, and Toone, EJ. "Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold." Bioorg Med Chem 19.2 (January 15, 2011): 852-860. Full Text

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