Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
3218 French Science Center, Durham, NC 27708
(919) 660-1511



NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Fernhoff, NB, Derbyshire, ER, Underbakke, ES, and Marletta, MA. "Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide." J Biol Chem 287.51 (December 14, 2012): 43053-43062. Full Text

Carr, G, Derbyshire, ER, Caldera, E, Currie, CR, and Clardy, J. "Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp." J Nat Prod 75.10 (October 26, 2012): 1806-1809. Full Text

Derbyshire, ER, Prudêncio, M, Mota, MM, and Clardy, J. "Liver-stage malaria parasites vulnerable to diverse chemical scaffolds." Proc Natl Acad Sci U S A 109.22 (May 29, 2012): 8511-8516. Full Text

Derbyshire, ER, Mazitschek, R, and Clardy, J. "Characterization of Plasmodium liver stage inhibition by halofuginone." ChemMedChem 7.5 (May 2012): 844-849. Full Text

Derbyshire, ER, and Marletta, MA. "Structure and regulation of soluble guanylate cyclase." Annu Rev Biochem 81 (2012): 533-559. (Review) Full Text

Dong, CK, Urgaonkar, S, Cortese, JF, Gamo, F-J, Garcia-Bustos, JF, Lafuente, MJ, Patel, V, Ross, L, Coleman, BI, Derbyshire, ER, Clish, CB, Serrano, AE, Cromwell, M, Barker, RH, Dvorin, JD, Duraisingh, MT, Wirth, DF, Clardy, J, and Mazitschek, R. "Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors." Chem Biol 18.12 (December 23, 2011): 1602-1610. Full Text

Derbyshire, ER, Mota, MM, and Clardy, J. "The next opportunity in anti-malaria drug discovery: the liver stage." PLoS Pathog 7.9 (September 2011): e1002178-. Full Text

Derbyshire, ER, Winter, MB, Ibrahim, M, Deng, S, Spiro, TG, and Marletta, MA. "Probing domain interactions in soluble guanylate cyclase." Biochemistry 50.20 (May 24, 2011): 4281-4290. Full Text

Ibrahim, M, Derbyshire, ER, Soldatova, AV, Marletta, MA, and Spiro, TG. "Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence." Biochemistry 49.23 (June 15, 2010): 4864-4871. Full Text