Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
3218 French Science Center, Durham, NC 27708
(919) 660-1511



NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Derbyshire, ER, Deng, S, and Marletta, MA. "Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding." J Biol Chem 285.23 (June 4, 2010): 17471-17478. Full Text

Ibrahim, M, Derbyshire, ER, Marletta, MA, and Spiro, TG. "Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy." Biochemistry 49.18 (May 11, 2010): 3815-3823. Full Text

Fernhoff, NB, Derbyshire, ER, and Marletta, MA. "A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase." Proc Natl Acad Sci U S A 106.51 (December 22, 2009): 21602-21607. Full Text

Derbyshire, ER, Fernhoff, NB, Deng, S, and Marletta, MA. "Nucleotide regulation of soluble guanylate cyclase substrate specificity." Biochemistry 48.31 (August 11, 2009): 7519-7524. Full Text

Ibrahim, M, Derbyshire, ER, Marletta, MA, and Spiro, TG. "Interaction of allosteric effectors with soluble guanylate cyclase heme domains: Role of heme distortion and propionate hydrogen bonding on synergistic activation." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 237 (March 22, 2009).

Derbyshire, ER, and Marletta, MA. "Biochemistry of soluble guanylate cyclase." Handb Exp Pharmacol 191 (2009): 17-31. (Review) Full Text

Winger, JA, Derbyshire, ER, Lamers, MH, Marletta, MA, and Kuriyan, J. "The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. (Published online)" BMC Struct Biol 8 (October 7, 2008): 42-. Full Text

Derbyshire, ER, Gunn, A, Ibrahim, M, Spiro, TG, Britt, RD, and Marletta, MA. "Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes." Biochemistry 47.12 (March 25, 2008): 3892-3899. Full Text

Martin, NI, Derbyshire, ER, and Marletta, MA. "Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1." Bioorg Med Chem Lett 17.17 (September 1, 2007): 4938-4941. Full Text