Faculty Profiles

Dewey G. McCafferty
Professor of Chemistry
B120 LSRC, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346
(919) 660-1516
(919) 660-1605



Ph.D., University of North Carolina at Chapel Hill 1995

B.S., North Carolina State University 1990

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Bentley, ML, Gaweska, H, Kielec, JM, and McCafferty, DG. "Engineering the substrate specificity of Staphylococcus aureus sortase A: The β6/β7 loop from SrtB confers npqtn recognition to SrtA." Journal of Biological Chemistry 282.9 (2007): 6571-6581. Full Text

Frankel, BA, Tong, Y, Bentley, ML, Fitzgerald, MC, and McCafferty, DG. "Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA." Biochemistry 46.24 (2007): 7269-7278. Full Text

McCafferty, DG. "Crossing a biological velvet rope." ACS Chem Biol 1.6 (July 21, 2006): 339-340. (Review) Full Text

Lee, MG, Wynder, C, Schmidt, DM, McCafferty, DG, and Shiekhattar, R. "Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive Medications." Chemistry and Biology 13.6 (2006): 563-567. Full Text

Barkallah, S, Schneider, SL, and McCafferty, DG. "Facile syntheses of conformationally constrained analogues of lysine and homoglutamic acid." Tetrahedron Letters 46.30 (2005): 4985-4987. Full Text

Frankel, BA, Kruger, RG, Robinson, DE, Kelleher, NL, and McCafferty, DG. "Staphylococcus aureus sortase transpeptidase SrtA: Insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism." Biochemistry 44.33 (2005): 11188-11200. Full Text

Striplin, DR, Reece, SY, McCafferty, DG, Wall, CG, Friesen, DA, Erickson, BW, and Meyer, TJ. "Solvent Dependence of Intramolecular Electron Transfer in a Helical Oligoproline Assembly." Journal of the American Chemical Society 126.16 (2004): 5282-5291. Full Text

Kruger, RG, Barkallah, S, Frankel, BA, and McCafferty, DG. "Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics." Bioorganic and Medicinal Chemistry 12.13 (2004): 3723-3729. Full Text

Gaweska, H, Kielec, J, and McCafferty, D. "A suppression strategy for antibiotic discovery." Chemistry and Biology 11.10 (2004): 1330-1332. Full Text

Frankel, BA, and McCafferty, DG. "Profiling natural product biosynthesis." Chemistry and Biology 11.3 (2004): 290-291. Full Text