Faculty Profiles

Dewey G. McCafferty
Professor of Chemistry
Office: 
B120 LSRC, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346
Phone: 
(919) 660-1516
Fax: 
(919) 660-1605

Overview

Education:

Ph.D., University of North Carolina at Chapel Hill 1995

B.S., North Carolina State University 1990

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Schmidt, DMZ, and McCafferty, DG. "trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1." Biochemistry 46.14 (April 2007): 4408-4416. Full Text

Bentley, ML, Gaweska, H, Kielec, JM, and McCafferty, DG. "Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA." The Journal of Biological Chemistry 282.9 (March 2007): 6571-6581. Full Text

McCafferty, DG. "Crossing a biological velvet rope." ACS Chem Biol 1.6 (July 21, 2006): 339-340. (Review) Full Text

Lee, MG, Wynder, C, Schmidt, DM, McCafferty, DG, and Shiekhattar, R. "Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications." Chemistry & Biology 13.6 (June 2006): 563-567. Full Text

Barkallah, S, Schneider, SL, and McCafferty, DG. "Facile syntheses of conformationally constrained analogues of lysine and homoglutamic acid." Tetrahedron Letters 46.30 (2005): 4985-4987. Full Text

Frankel, BA, Kruger, RG, Robinson, DE, Kelleher, NL, and McCafferty, DG. "Staphylococcus aureus sortase transpeptidase SrtA: Insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism." Biochemistry 44.33 (2005): 11188-11200. Full Text

Frankel, BA, Bentley, M, Kruger, RG, and McCafferty, DG. "Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus." Journal of the American Chemical Society 126.11 (March 2004): 3404-3405. Full Text

Gaweska, H, Kielec, J, and McCafferty, D. "A suppression strategy for antibiotic discovery." Chemistry and Biology 11.10 (2004): 1330-1332. Full Text

Frankel, BA, and McCafferty, DG. "Profiling natural product biosynthesis." Chemistry and Biology 11.3 (2004): 290-291. Full Text

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