Faculty Profiles

Dewey G. McCafferty
Professor of Chemistry
B120 LSRC, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346
(919) 660-1516
(919) 660-1605



Ph.D., University of North Carolina at Chapel Hill 1995

B.S., North Carolina State University 1990

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Schmidt, JW, Greenough, A, Burns, M, Luteran, AE, and McCafferty, DG. "Generation of ramoplanin-resistant Staphylococcus aureus." FEMS Microbiol Lett 310.2 (September 1, 2010): 104-111. Full Text

Clancy, KW, Melvin, JA, and McCafferty, DG. "Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition." Biopolymers 94.4 (2010): 385-396. (Review) Full Text

Hamburger, JB, Hoertz, AJ, Lee, A, Senturia, RJ, McCafferty, DG, and Loll, PJ. "A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface." Proc Natl Acad Sci U S A 106.33 (August 18, 2009): 13759-13764. Full Text

Deshmukh, HS, Hamburger, JB, Ahn, SH, McCafferty, DG, Yang, SR, and Fowler, VG. "Critical role of NOD2 in regulating the immune response to Staphylococcus aureus." Infect Immun 77.4 (April 2009): 1376-1382. Full Text

Race, PR, Bentley, ML, Melvin, JA, Crow, A, Hughes, RK, Smith, WD, Sessions, RB, Kehoe, MA, McCafferty, DG, and Banfield, MJ. "Crystal Structure of streptococcus pyogenes Sortase A: Implications for sortase mechanism." Journal of Biological Chemistry 284.11 (2009): 6924-6933. Full Text

Gaweska, H, Pozzi, MH, Schmidt, DMZ, McCafferty, DG, and Fitzpatrick, PF. "Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1." Biochemistry 48.23 (2009): 5440-5445. Full Text

Gooden, DM, Schmidt, DMZ, Pollock, JA, Kabadi, AM, and McCafferty, DG. "Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B." Bioorg Med Chem Lett 18.10 (May 15, 2008): 3047-3051. Full Text

Bentley, ML, Lamb, EC, and McCafferty, DG. "Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus." Journal of Biological Chemistry 283.21 (2008): 14762-14771. Full Text

Schmidt, DMZ, and McCafferty, DG. "trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1." Biochemistry 46.14 (April 10, 2007): 4408-4416. Full Text