Faculty Profiles

Dewey G. McCafferty
Professor of Chemistry
B120 LSRC, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346
(919) 660-1516
(919) 660-1605



Ph.D., University of North Carolina at Chapel Hill 1995

B.S., North Carolina State University 1990

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Frankel, BA, Bentley, M, Kruger, RG, and McCafferty, DG. "Vinyl Sulfones: Inhibitors of SrtA, a Transpeptidase Required for Cell Wall Protein Anchoring and Virulence in Staphylococcus aureus." Journal of the American Chemical Society 126.11 (2004): 3404-3405. Full Text

Kruger, RG, Otvos, B, Frankel, BA, Bentley, M, Dostal, P, and McCafferty, DG. "Analysis of the Substrate Specificity of the Staphylococcus aureus Sortase Transpeptidase SrtA." Biochemistry 43.6 (2004): 1541-1551. Full Text

Loyola, A, He, S, Oh, S, McCafferty, DG, and Reinberg, D. "Techniques Used to Study Transcription on Chromatin Templates." Methods in Enzymology 377 (2004): 474-499. Full Text

He, S, Bauman, D, Davis, JS, Loyola, A, Nishioka, K, Gronlund, JL, Reinberg, D, Meng, F, Kelleher, N, and McCafferty, DG. "Facile synthesis of site-specifically acetylated and methylated histone proteins: Reagents for evaluation of the histone code hypothesis." Proceedings of the National Academy of Sciences of the United States of America 100.21 (2003): 12033-12038. Full Text

Kapustin, GV, Fejér, G, Gronlund, JL, McCafferty, DG, Seto, E, and Etzkorn, FA. "Phosphorus-based SAHA analogues as histone deacetylase inhibitors." Organic Letters 5.17 (2003): 3053-3056. Full Text

Huang, C-Y, He, S, DeGrado, WF, McCafferty, DG, and Gai, F. "Light-induced helix formation." Journal of the American Chemical Society 124.43 (2002): 12674-12675. Full Text

Cudic, P, Behenna, DC, Kranz, JK, Kruger, RG, Wand, AJ, Veklich, YI, Weisel, JW, and McCafferty, DG. "Functional Analysis of the Lipoglycodepsipeptide Antibiotic Ramoplanin." Chemistry and Biology 9.8 (2002): 897-906. Full Text

McCafferty, DG, Cudic, P, Frankel, BA, Barkallah, S, Kruger, RG, and Li, W. "Chemistry and biology of the ramoplanin family of peptide antibiotics." Biopolymers - Peptide Science Section 66.4 (2002): 261-284. Full Text

Cudic, P, Kranz, JK, Behenna, DC, Kruger, RG, Tadesse, H, Wand, AJ, Veklich, YI, Weisel, JW, and McCafferty, DG. "Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: Minimal structural requirements for intermolecular complexation and fibril formation." Proceedings of the National Academy of Sciences of the United States of America 99.11 (2002): 7384-7389. Full Text