Faculty Profiles

Dewey G. McCafferty
Professor of Chemistry
B120 LSRC, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346
(919) 660-1516
(919) 660-1605



Ph.D., University of North Carolina at Chapel Hill 1995

B.S., North Carolina State University 1990

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Frankel, BA, Tong, Y, Bentley, ML, Fitzgerald, MC, and McCafferty, DG. "Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA." Biochemistry 46.24 (2007): 7269-7278. Full Text

Bentley, ML, Gaweska, H, Kielec, JM, and McCafferty, DG. "Engineering the substrate specificity of Staphylococcus aureus sortase A: The β6/β7 loop from SrtB confers npqtn recognition to SrtA." Journal of Biological Chemistry 282.9 (2007): 6571-6581. Full Text

McCafferty, DG. "Crossing a biological velvet rope." ACS Chem Biol 1.6 (July 21, 2006): 339-340. (Review) Full Text

Lee, MG, Wynder, C, Schmidt, DM, McCafferty, DG, and Shiekhattar, R. "Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive Medications." Chemistry and Biology 13.6 (2006): 563-567. Full Text

Barkallah, S, Schneider, SL, and McCafferty, DG. "Facile syntheses of conformationally constrained analogues of lysine and homoglutamic acid." Tetrahedron Letters 46.30 (2005): 4985-4987. Full Text

Frankel, BA, Kruger, RG, Robinson, DE, Kelleher, NL, and McCafferty, DG. "Staphylococcus aureus sortase transpeptidase SrtA: Insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism." Biochemistry 44.33 (2005): 11188-11200. Full Text

Striplin, DR, Reece, SY, McCafferty, DG, Wall, CG, Friesen, DA, Erickson, BW, and Meyer, TJ. "Solvent Dependence of Intramolecular Electron Transfer in a Helical Oligoproline Assembly." Journal of the American Chemical Society 126.16 (2004): 5282-5291. Full Text

Kruger, RG, Barkallah, S, Frankel, BA, and McCafferty, DG. "Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics." Bioorganic and Medicinal Chemistry 12.13 (2004): 3723-3729. Full Text

Gaweska, H, Kielec, J, and McCafferty, D. "A suppression strategy for antibiotic discovery." Chemistry and Biology 11.10 (2004): 1330-1332. Full Text

Frankel, BA, and McCafferty, DG. "Profiling natural product biosynthesis." Chemistry and Biology 11.3 (2004): 290-291. Full Text