Faculty Profiles

Dewey G. McCafferty
Professor of Chemistry
B120 LSRC, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346
(919) 660-1516
(919) 660-1605



Ph.D., University of North Carolina at Chapel Hill 1995

B.S., North Carolina State University 1990

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Folk, DS, Torosian, JC, Hwang, S, McCafferty, DG, and Franz, KJ. "Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe." Angew Chem Int Ed Engl 51.43 (October 22, 2012): 10795-10799. Full Text

Pollock, JA, Larrea, MD, Jasper, JS, McDonnell, DP, and McCafferty, DG. "Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners." ACS Chem Biol 7.7 (July 20, 2012): 1221-1231. Full Text

Weinberg, DR, Gagliardi, CJ, Hull, JF, Murphy, CF, Kent, CA, Westlake, BC, Paul, A, Ess, DH, McCafferty, DG, and Meyer, TJ. "Proton-coupled electron transfer." Chemical Reviews 112.7 (July 2012): 4016-4093. (Review) Full Text

Hoertz, AJ, Hamburger, JB, Gooden, DM, Bednar, MM, and McCafferty, DG. "Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2." Bioorg Med Chem 20.2 (January 15, 2012): 859-865. Full Text

Melvin, JA, Murphy, CF, Dubois, LG, Thompson, JW, Moseley, MA, and McCafferty, DG. "Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation." Biochemistry 50.35 (September 2011): 7591-7599. Full Text

Jorgensen, I, Bednar, MM, Amin, V, Davis, BK, Ting, JPY, McCafferty, DG, and Valdivia, RH. "The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence." Cell Host & Microbe 10.1 (July 2011): 21-32. Full Text

Cropp, TA, and McCafferty, DG. "Found in translation: applications of protein and peptide molecular diversity." Current Opinion in Chemical Biology 15.3 (June 2011): 347-349. Full Text

Hwang, S, Schmitt, AA, Luteran, AE, Toone, EJ, and McCafferty, DG. "Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST." Biochemistry 50.4 (February 1, 2011): 546-557. Full Text

Hu, X, Hu, H, Melvin, JA, Clancy, KW, McCafferty, DG, and Yang, W. "Autocatalytic intramolecular isopeptide bond formation in gram-positive bacterial pili: a QM/MM simulation." Journal of the American Chemical Society 133.3 (January 2011): 478-485. Full Text