Faculty Profiles

Dewey G. McCafferty
Professor of Chemistry
Office: 
B120 LSRC, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346
Phone: 
(919) 660-1516
Fax: 
(919) 660-1605

Overview

Education:

Ph.D., University of North Carolina at Chapel Hill 1995

B.S., North Carolina State University 1990

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Biniossek, ML, Niemer, M, Maksimchuk, K, Mayer, B, Fuchs, J, Huesgen, PF, McCafferty, DG, Turk, B, Fritz, G, Mayer, J, Haecker, G, Mach, L, and Schilling, O. "Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics." Molecular & cellular proteomics : MCP 15.7 (July 2016): 2515-2524. Full Text

Burg, JM, Gonzalez, JJ, Maksimchuk, KR, and McCafferty, DG. "Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones." Biochemistry 55.11 (March 2016): 1652-1662. Full Text

Maksimchuk, KR, Alser, KA, Mou, R, Valdivia, RH, and McCafferty, DG. "The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins." PloS one 11.2 (January 2016): e0147233-. Full Text

Burg, JM, Makhoul, AT, Pemble, CW, Link, JE, Heller, FJ, and McCafferty, DG. "A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity." FEBS letters 589.18 (August 2015): 2340-2346. Full Text

Burg, JM, Link, JE, Morgan, BS, Heller, FJ, Hargrove, AE, and McCafferty, DG. "KDM1 class flavin-dependent protein lysine demethylases." Biopolymers 104.4 (July 2015): 213-246. (Review) Full Text

Snavely, EA, Kokes, M, Dunn, JD, Saka, HA, Nguyen, BD, Bastidas, RJ, McCafferty, DG, and Valdivia, RH. "Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches." Pathogens and disease 71.3 (August 2014): 336-351. Full Text

Qi, Y, Amiram, M, Gao, W, McCafferty, DG, and Chilkoti, A. "Sortase-catalyzed initiator attachment enables high yield growth of a stealth polymer from the C terminus of a protein." Macromol Rapid Commun 34.15 (August 2013): 1256-1260. Full Text

Bellucci, JJ, Amiram, M, Bhattacharyya, J, McCafferty, D, and Chilkoti, A. "Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides." Angew Chem Int Ed Engl 52.13 (March 25, 2013): 3703-3708. Full Text

Qi, Y, Amiram, M, Gao, W, McCafferty, DG, and Chilkoti, A. "Sortase-Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein." Macromolecular Rapid Communications 34.15 (2013): 1256-1260. Full Text

McCafferty, DG, and Melvin, JA. "Sortases." Handbook of Proteolytic Enzymes 2 (2013): 2459-2465. Full Text

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