Faculty Profiles

Ashutosh Chilkoti
Alan L. Kaganov Professor of Biomedical Engineering
1427 CIEMAS, Durham, NC 27708
(919) 660-5373
+1 919 660 5409



Ph.D., University of Washington 1991

Mozhdehi, D, Luginbuhl, KM, Simon, JR, Dzuricky, M, Berger, R, Varol, HS, Huang, FC, Buehne, KL, Mayne, NR, Weitzhandler, I, Bonn, M, Parekh, SH, and Chilkoti, A. "Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly. (Accepted)" Nature chemistry 10.5 (May 2018): 496-505. Full Text

Gilroy, CA, Roberts, S, and Chilkoti, A. "Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action. (Accepted)" Journal of controlled release : official journal of the Controlled Release Society 277 (May 2018): 154-164. Full Text

Costa, SA, Simon, JR, Amiram, M, Tang, L, Zauscher, S, Brustad, EM, Isaacs, FJ, and Chilkoti, A. "Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides." Advanced materials (Deerfield Beach, Fla.) 30.5 (February 2018). Full Text

Li, L, Li, NK, Tu, Q, Im, O, Mo, C-K, Han, W, Fuss, WH, Carroll, NJ, Chilkoti, A, Yingling, YG, Zauscher, S, and López, GP. "Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers." Biomacromolecules 19.2 (February 2018): 298-306. Full Text

Mastria, EM, Cai, LY, Kan, MJ, Li, X, Schaal, JL, Fiering, S, Gunn, MD, Dewhirst, MW, Nair, SK, and Chilkoti, A. "Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity." Journal of controlled release : official journal of the Controlled Release Society 269 (January 2018): 364-373. Full Text

Luginbuhl, KM, Mozhdehi, D, Dzuricky, M, Yousefpour, P, Huang, FC, Mayne, NR, Buehne, KL, and Chilkoti, A. "Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs." Angewandte Chemie (International ed. in English) 56.45 (November 2017): 13979-13984. Full Text

Wang, J, Dzuricky, M, and Chilkoti, A. "The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles." Nano letters 17.10 (October 2017): 5995-6005. Full Text

Bhattacharyya, J, Ren, X-R, Mook, RA, Wang, J, Spasojevic, I, Premont, RT, Li, X, Chilkoti, A, and Chen, W. "Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth." Nanoscale 9.34 (August 22, 2017): 12709-12717. Full Text

Joh, DY, Hucknall, AM, Wei, Q, Mason, KA, Lund, ML, Fontes, CM, Hill, RT, Blair, R, Zimmers, Z, Achar, RK, Tseng, D, Gordan, R, Freemark, M, Ozcan, A, and Chilkoti, A. "Inkjet-printed point-of-care immunoassay on a nanoscale polymer brush enables subpicomolar detection of analytes in blood." Proceedings of the National Academy of Sciences of the United States of America 114.34 (August 7, 2017): E7054-E7062. Full Text

Wang, J, Bhattacharyya, J, Mastria, E, and Chilkoti, A. "A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles." Journal of controlled release : official journal of the Controlled Release Society 260 (August 2017): 100-110. Full Text


Bhattacharyya, J, Bellucci, JJ, and Chilkoti, A. "Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering." Biomaterials from Nature for Advanced Devices and Therapies. January 1, 2016. 106-126. Full Text

Hill, RT, and Chilkoti, A. "Surface Patterning." Biomaterials Science: An Introduction to Materials: Third Edition. January 1, 2013. 276-301. Full Text

Nusz, G, and Chilkoti, A. "Individual plasmonic nanostructures as label free biosensors." Nanoplasmonic Sensors. January 1, 2012. 105-126. Full Text

Liu, W, Mukerji, R, Li, X, Schaal, J, Bhattacharyya, J, Zalutsky, M, and Chilkoti, A. "Abstract 4583: In situ photocontrolled intratumoral depot for combined photodynamic therapy and brachytherapy for solid tumor." October 1, 2014. Full Text

Quiroz, FG, and Chilkoti, A. "The language of protein polymers." January 1, 2014. Full Text

Tang, L, Tjong, V, Gu, R, Chilkoti, A, and Zauscher, S. "Enzyme catalyzed polymerization of DNA amphiphiles that self-assemble into star-like micelles." September 8, 2013.

Garanger, E, Mac Ewan, S, Brulet, A, Bataille, L, Sandre, O, Chilkoti, A, and Lecommandoux, S. "Elastin-based amphiphilic copolymers as precision building blocks for controlled self-assembly." September 8, 2013.

Weinberger, A, Macewan, S, Schmatko, T, Schroder, A, Chilkoti, A, and Marques, CM. "Interactions of elastin-like polypeptides with model membranes on GUVs." July 2013.