Faculty Profiles

Ashutosh Chilkoti
Professor in the Department of Chemistry
1427 CIEMAS, Durham, NC 27708
(919) 660-5373
+1 919 660 5409



Ph.D., University of Washington 1991

Bhattacharyya, J, Weitzhandler, I, Ho, SB, McDaniel, JR, Li, X, Tang, L, Liu, J, Dewhirst, M, and Chilkoti, A. "Encapsulating a Hydrophilic Chemotherapeutic into Rod-Like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves Its Efficacy." Advanced Functional Materials 27.12 (March 2017): 1605421-1605421. Full Text

Widder, K, MacEwan, SR, Garanger, E, Núñez, V, Lecommandoux, S, Chilkoti, A, and Hinderberger, D. "Characterisation of hydration and nanophase separation during the temperature response in hydrophobic/hydrophilic elastin-like polypeptide (ELP) diblock copolymers." Soft matter 13.9 (March 2017): 1816-1822. Full Text

Ozer, I, and Chilkoti, A. "Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins." Bioconjugate Chemistry 28.3 (March 2017): 713-723. (Review) Full Text

Gonzalez, MA, Simon, JR, Ghoorchian, A, Scholl, Z, Lin, S, Rubinstein, M, Marszalek, P, Chilkoti, A, López, GP, and Zhao, X. "Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins." Advanced Materials (Deerfield Beach, Fla.) 29.10 (March 2017). Full Text

Joh, DY, McGuire, F, Abedini-Nassab, R, Andrews, JB, Achar, RK, Zimmers, Z, Mozhdehi, D, Blair, R, Albarghouthi, F, Oles, W, Richter, J, Fontes, CM, Hucknall, AM, Yellen, BB, Franklin, AD, and Chilkoti, A. "Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments." ACS applied materials & interfaces 9.6 (February 2017): 5522-5529. Full Text

Wang, J, MacEwan, SR, and Chilkoti, A. "Quantitative Mapping of the Spatial Distribution of Nanoparticles in Endo-Lysosomes by Local pH." Nano Letters 17.2 (February 2017): 1226-1232. Full Text

MacEwan, SR, Weitzhandler, I, Hoffmann, I, Genzer, J, Gradzielski, M, and Chilkoti, A. "Phase Behavior and Self-Assembly of Perfectly Sequence-Defined and Monodisperse Multiblock Copolypeptides." Biomacromolecules 18.2 (February 2017): 599-609. Full Text

Banskota, S, Yousefpour, P, and Chilkoti, A. "Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds." Macromolecular bioscience 17.1 (January 2017). (Review) Full Text

Luginbuhl, KM, Schaal, JL, Umstead, B, Mastria, EM, Li, X, Banskota, S, Arnold, S, Feinglos, M, D'Alessio, D, and Chilkoti, A. "One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer." Nature biomedical engineering 1 (January 2017). Full Text

Kwok, KWH, Dong, W, Marinakos, SM, Liu, J, Chilkoti, A, Wiesner, MR, Chernick, M, and Hinton, DE. "Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation." Nanotoxicology 10.9 (November 2016): 1306-1317. Full Text Open Access Copy


Liu, W, Dreher, MR, Chow, DC, Zalutsky, MR, and Chilkoti, A. "Tracking the in vivo fate of recombinant polypeptides by isotopic labeling." 3rd International Nanomedicine and Drug Delivery Symposium. September 26, 2005 - September 27, 2005. Baltimore, MD.: ELSEVIER SCIENCE BV, August 28, 2006. Full Text

Wong, JY, Plant, AL, Schmidt, CE, Shea, L, Coury, AJ, Chen, CS, Barron, AE, Klok, HA, Deming, TJ, Saltzman, WM, Chilkoti, A, Luo, D, and Uhrich, K. "Materials Research Society Symposium Proceedings: Preface." December 1, 2004.

Valiaev, A, Lim, DW, Clark, R, Chilkoti, A, and Zauscher, S. "Mechanics of stimulus-responsive elastin-like polypeptides studied by force spectroscopy." August 22, 2004.

Prohaska, S, Dreher, M, Dewhirst, MW, Chilkoti, A, Pries, AR, Westerhoff, M, and Cornelissen, AJM. "3-D reconstruction of tumor vascular networks." 2004.