Faculty Profiles

Ashutosh Chilkoti
Alan L. Kaganov Professor of Biomedical Engineering
CIEMAS 3381, Durham, NC 27708
(919) 660-5373
+1 919 660 5409



Ph.D., University of Washington 1991

Bhattacharyya, J, Bellucci, JJ, and Chilkoti, A. "Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering." Biomaterials from Nature for Advanced Devices and Therapies. January 1, 2016. 106-126. Full Text

Hill, RT, and Chilkoti, A. "Surface Patterning." Biomaterials Science: An Introduction to Materials: Third Edition. January 1, 2013. 276-301. Full Text

Wang, J, Bhattacharyya, J, Mastria, E, and Chilkoti, A. "A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles." Journal of controlled release : official journal of the Controlled Release Society 260 (August 2017): 100-110. Full Text

Tang, L, Navarro, LA, Chilkoti, A, and Zauscher, S. "High-Molecular-Weight Polynucleotides by Transferase-Catalyzed Living Chain-Growth Polycondensation." Angewandte Chemie (International ed. in English) 56.24 (June 2017): 6778-6782. Full Text

MacEwan, SR, and Chilkoti, A. "From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers." Angewandte Chemie (International ed. in English) 56.24 (June 2017): 6712-6733. (Review) Full Text

Simon, JR, Carroll, NJ, Rubinstein, M, Chilkoti, A, and López, GP. "Programming molecular self-assembly of intrinsically disordered proteins containing sequences of low complexity." Nature chemistry 9.6 (June 2017): 509-515. Full Text

Han, W, Chilkoti, A, and López, GP. "Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release." Nanoscale 9.18 (May 2017): 6178-6186. Full Text

Weinberger, A, Walter, V, MacEwan, SR, Schmatko, T, Muller, P, Schroder, AP, Chilkoti, A, and Marques, CM. "Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes." Scientific Reports 7 (March 6, 2017). Full Text

Bhattacharyya, J, Weitzhandler, I, Ho, SB, McDaniel, JR, Li, X, Tang, L, Liu, J, Dewhirst, M, and Chilkoti, A. "Encapsulating a Hydrophilic Chemotherapeutic into Rod-Like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves Its Efficacy." Advanced Functional Materials 27.12 (March 2017): 1605421-1605421. Full Text

Widder, K, MacEwan, SR, Garanger, E, Núñez, V, Lecommandoux, S, Chilkoti, A, and Hinderberger, D. "Characterisation of hydration and nanophase separation during the temperature response in hydrophobic/hydrophilic elastin-like polypeptide (ELP) diblock copolymers." Soft matter 13.9 (March 2017): 1816-1822. Full Text

Ozer, I, and Chilkoti, A. "Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins." Bioconjugate chemistry 28.3 (March 2017): 713-723. (Review) Full Text

Gonzalez, MA, Simon, JR, Ghoorchian, A, Scholl, Z, Lin, S, Rubinstein, M, Marszalek, P, Chilkoti, A, López, GP, and Zhao, X. "Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins." Advanced materials (Deerfield Beach, Fla.) 29.10 (March 2017). Full Text


Liu, W, Mukerji, R, Li, X, Schaal, J, Bhattacharyya, J, Zalutsky, M, and Chilkoti, A. "Abstract 4583: In situ photocontrolled intratumoral depot for combined photodynamic therapy and brachytherapy for solid tumor." October 1, 2014. Full Text

Quiroz, FG, and Chilkoti, A. "The language of protein polymers." January 1, 2014. Full Text

Tang, L, Tjong, V, Gu, R, Chilkoti, A, and Zauscher, S. "Enzyme catalyzed polymerization of DNA amphiphiles that self-assemble into star-like micelles." September 8, 2013.

Garanger, E, Mac Ewan, S, Brulet, A, Bataille, L, Sandre, O, Chilkoti, A, and Lecommandoux, S. "Elastin-based amphiphilic copolymers as precision building blocks for controlled self-assembly." September 8, 2013.

Weinberger, A, Macewan, S, Schmatko, T, Schroder, A, Chilkoti, A, and Marques, CM. "Interactions of elastin-like polypeptides with model membranes on GUVs." July 2013.