Faculty Profiles

Amanda Hargrove
Assistant Professor of Chemistry
3219 French Science Center, Box 90346, Durham, NC 27708
(919) 660-1522
(919) 660-1605



NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas at Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Donlic, A, Morgan, BS, Xu, JL, Liu, A, Roble, C, and Hargrove, AE. "Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold." Angewandte Chemie (International Ed. in English) (August 22, 2018). Full Text

Morgan, BS, Forte, JE, and Hargrove, AE. "Insights into the development of chemical probes for RNA." Nucleic Acids Research (August 8, 2018). Full Text

Donlic, A, and Hargrove, AE. "Targeting RNA in mammalian systems with small molecules." Wiley interdisciplinary reviews. RNA (May 3, 2018): e1477-. (Review) Full Text

Eubanks, CS, and Hargrove, AE. "Sensing the impact of environment on small molecule differentiation of RNA sequences." Chemical Communications (Cambridge, England) 53.100 (December 2017): 13363-13366. Full Text

Morgan, BS, Forte, JE, Culver, RN, Zhang, Y, and Hargrove, AE. "Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands." Angewandte Chemie (International Ed. in English) 56.43 (October 2017): 13498-13502. Full Text

Patwardhan, NN, Ganser, LR, Kapral, GJ, Eubanks, CS, Lee, J, Sathyamoorthy, B, Al-Hashimi, HM, and Hargrove, AE. "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR." Medchemcomm 8.5 (May 2017): 1022-1036. Full Text

Eubanks, CS, Forte, JE, Kapral, GJ, and Hargrove, AE. "Small Molecule-Based Pattern Recognition To Classify RNA Structure." Journal of the American Chemical Society 139.1 (January 2017): 409-416. Full Text

McFadden, EJ, and Hargrove, AE. "Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin." Biochemistry 55.11 (March 2016): 1615-1630. (Review) Full Text

Burg, JM, Link, JE, Morgan, BS, Heller, FJ, Hargrove, AE, and McCafferty, DG. "KDM1 class flavin-dependent protein lysine demethylases." Biopolymers 104.4 (July 2015): 213-246. (Review) Full Text

Hargrove, AE, Martinez, TF, Hare, AA, Kurmis, AA, Phillips, JW, Sud, S, Pienta, KJ, and Dervan, PB. "Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide." PloS one 10.11 (January 2015): e0143161-. Full Text