Faculty Profiles

Amanda Elaine Hargrove
Assistant Professor of Chemistry
Office: 
3219 French Science Center, Durham, NC 27708
Phone: 
(919) 660-1522
Fax: 
(919) 660-1605

Overview

Education:

NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas at Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Eubanks, CS, and Hargrove, AE. "Sensing the impact of environment on small molecule differentiation of RNA sequences." Chemical communications (Cambridge, England) (December 4, 2017). Full Text

Morgan, BS, Forte, JE, Culver, RN, Zhang, Y, and Hargrove, AE. "Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands." Angewandte Chemie (International ed. in English) 56.43 (October 2017): 13498-13502. Full Text

Patwardhan, NN, Ganser, LR, Kapral, GJ, Eubanks, CS, Lee, J, Sathyamoorthy, B, Al-Hashimi, HM, and Hargrove, AE. "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR." MedChemComm 8.5 (May 2017): 1022-1036. Full Text

Eubanks, CS, Forte, JE, Kapral, GJ, and Hargrove, AE. "Small Molecule-Based Pattern Recognition To Classify RNA Structure." Journal of the American Chemical Society 139.1 (January 2017): 409-416. Full Text

McFadden, EJ, and Hargrove, AE. "Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin." Biochemistry 55.11 (March 2016): 1615-1630. (Review) Full Text

Burg, JM, Link, JE, Morgan, BS, Heller, FJ, Hargrove, AE, and McCafferty, DG. "KDM1 class flavin-dependent protein lysine demethylases." Biopolymers 104.4 (July 2015): 213-246. (Review) Full Text

Hargrove, AE, Martinez, TF, Hare, AA, Kurmis, AA, Phillips, JW, Sud, S, Pienta, KJ, and Dervan, PB. "Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide." PloS one 10.11 (January 2015): e0143161-. Full Text

Morgan, BS, and Hargrove, AE. "Synthetic receptors for oligonucleotides and nucleic acids." Monographs in Supramolecular Chemistry 2015-January.14 (January 1, 2015): 253-325.

Nickols, NG, Szablowski, JO, Hargrove, AE, Li, BC, Raskatov, JA, and Dervan, PB. "Activity of a Py-Im polyamide targeted to the estrogen response element." Molecular Cancer Therapeutics 12.5 (2013): 675-684. Full Text

Raskatov, JA, Nickols, NG, Hargrove, AE, Marinov, GK, Wold, B, and Dervan, PB. "Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide." Proceedings of the National Academy of Sciences of the United States of America 109.40 (2012): 16041-16045. Full Text

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