Faculty Profiles

Amanda Elaine Hargrove
Assistant Professor of Chemistry
Office: 
3219 French Science Center, Durham, NC 27708
Phone: 
(919) 660-1522
Fax: 
(919) 660-1605

Overview

Education:

Nih Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas at Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Morgan, BS, Forte, JE, Culver, RN, Zhang, Y, and Hargrove, AE. "Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-targeted Bioactive Ligands." Angewandte Chemie (International ed. in English) (August 15, 2017). Full Text

Patwardhan, NN, Ganser, LR, Kapral, GJ, Eubanks, CS, Lee, J, Sathyamoorthy, B, Al-Hashimi, HM, and Hargrove, AE. "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR." MedChemComm 8.5 (May 2017): 1022-1036. Full Text

Eubanks, CS, Forte, JE, Kapral, GJ, and Hargrove, AE. "Small Molecule-Based Pattern Recognition To Classify RNA Structure." Journal of the American Chemical Society 139.1 (January 2017): 409-416. Full Text

McFadden, EJ, and Hargrove, AE. "Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin." Biochemistry 55.11 (March 2016): 1615-1630. (Review) Full Text

Burg, JM, Link, JE, Morgan, BS, Heller, FJ, Hargrove, AE, and McCafferty, DG. "KDM1 class flavin-dependent protein lysine demethylases." Biopolymers 104.4 (July 2015): 213-246. (Review) Full Text

Morgan, BS, and Hargrove, AE. "Synthetic receptors for oligonucleotides and nucleic acids." Monographs in Supramolecular Chemistry 2015-January.14 (January 1, 2015): 253-325.

Hargrove, AE, Martinez, TF, Hare, AA, Kurmis, AA, Phillips, JW, Sud, S, Pienta, KJ, and Dervan, PB. "Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide." PloS one 10.11 (January 2015): e0143161-. Full Text

Nickols, NG, Szablowski, JO, Hargrove, AE, Li, BC, Raskatov, JA, and Dervan, PB. "Activity of a Py-Im polyamide targeted to the estrogen response element." Molecular Cancer Therapeutics 12.5 (2013): 675-684. Full Text

Raskatov, JA, Nickols, NG, Hargrove, AE, Marinov, GK, Wold, B, and Dervan, PB. "Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide." Proceedings of the National Academy of Sciences of the United States of America 109.40 (2012): 16041-16045. Full Text

Hargrove, AE, Raskatov, JA, Meier, JL, Montgomery, DC, and Dervan, PB. "Characterization and solubilization of pyrrole-imidazole polyamide aggregates." Journal of Medicinal Chemistry 55.11 (2012): 5425-5432. Full Text

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