Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Kachadourian, R, Flaherty, MM, Crumbliss, AL, Patel, M, and Day, BJ. "Synthesis and in vitro antioxidant properties of manganese(III) beta-octabromo-meso-tetrakis(4-carboxyphenyl)porphyrin." J Inorg Biochem 95.4 (July 1, 2003): 240-248.

Gabricević, M, and Crumbliss, AL. "Kinetics and mechanism of iron(III)-nitrilotriacetate complex reactions with phosphate and acetohydroxamic acid." Inorg Chem 42.13 (June 30, 2003): 4098-4101. Full Text

Dhungana, S, Miller, MJ, Dong, L, Ratledge, C, and Crumbliss, AL. "Iron chelation properties of an extracellular siderophore exochelin MN." J Am Chem Soc 125.25 (June 25, 2003): 7654-7663. Full Text

Dhungana, S, Taboy, CH, Anderson, DS, Vaughan, KG, Aisen, P, Mietzner, TA, and Crumbliss, AL. "The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin." Proc Natl Acad Sci U S A 100.7 (April 1, 2003): 3659-3664. Full Text

Dhungana, S, Heggemann, S, Gebhardt, P, Möllmann, U, and Crumbliss, AL. "Fe(III) coordination properties of a new saccharide-based exocyclic trihydroxamate analogue of ferrichrome." Inorg Chem 42.1 (January 13, 2003): 42-50. Full Text

Weaver, KD, and Crumbliss, AL. "High-Resolution Structure of an Alternate Form of the Ferric Ion Binding Protein from Haemophilus influenzae." Chemtracts 16.12 (2003): 715-721.

Wirgau, JI, and Crumbliss, AL. "Carrier-facilitated bulk liquid membrane transport of iron(III) hydroxamate complexes utilizing a labile recognition agent and amine recognition in the second coordination sphere." Journal of the Chemical Society. Dalton Transactions 19 (2003): 3680-3685.

Boukhalfa, H, and Crumbliss, AL. "Chemical aspects of siderophore mediated iron transport." Biometals 15.4 (December 2002): 325-339. (Review)

Bonaventura, C, Taboy, CH, Low, PS, Stevens, RD, Lafon, C, and Crumbliss, AL. "Heme redox properties of S-nitrosated hemoglobin A0 and hemoglobin S: implications for interactions of nitric oxide with normal and sickle red blood cells." J Biol Chem 277.17 (April 26, 2002): 14557-14563. Full Text

Wirgau, JI, Spasojević, I, Boukhalfa, H, Batinić-Haberle, I, and Crumbliss, AL. "Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid." Inorg Chem 41.6 (March 25, 2002): 1464-1473.

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