Faculty Profiles

Al L. Crumbliss
Professor Emeritus of Chemistry
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
(919) 660-1540



Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Parker Siburt, CJ, Mietzner, TA, and Crumbliss, AL. "FbpA--a bacterial transferrin with more to offer." Biochim Biophys Acta 1820.3 (March 2012): 379-392. (Review) Full Text

Tran, DT, Banerjee, S, Alayash, AI, Crumbliss, AL, and Fitzgerald, MC. "Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry." Anal Chem 84.3 (February 7, 2012): 1653-1660. Full Text

Crumbliss, AL, and Parker Siburt, CJ. "Iron Transport in Living Cells." (January 13, 2012): 483-549. (Chapter) Full Text

Harrington, JM, Winkelmann, G, Haselwandter, K, and Crumbliss, AL. "Fe(III)-complexes of the tripodal trishydroxamate siderophore basidiochrome: potential biological implications." J Inorg Biochem 105.12 (December 2011): 1670-1674. Full Text

Bonaventura, C, Henkens, R, Friedman, J, Siburt, CJP, Kraiter, D, and Crumbliss, AL. "Steric factors moderate conformational fluidity and contribute to the high proton sensitivity of Root effect hemoglobins." Biochim Biophys Acta 1814.10 (October 2011): 1261-1268. Full Text

Harrington, JM, Park, H, Ying, Y, Hong, J, and Crumbliss, AL. "Characterization of Fe(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: implications for the iron transport mechanism in mycobacteria." Metallomics : Integrated Biometal Science 3.5 (May 2011): 464-471. Full Text

Miller, MJ, Walz, AJ, Zhu, H, Wu, C, Moraski, G, Möllmann, U, Tristani, EM, Crumbliss, AL, Ferdig, MT, Checkley, L, Edwards, RL, and Boshoff, HI. "Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria." Journal of the American Chemical Society 133.7 (February 2011): 2076-2079. Full Text

Bonaventura, C, Henkens, R, De Jesus-Bonilla, W, Lopez-Garriga, J, Jia, Y, Alayash, AI, Siburt, CJP, and Crumbliss, AL. "Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite." Biochim Biophys Acta 1804.10 (October 2010): 1988-1995. Full Text

Harrington, JM, Chittamuru, S, Dhungana, S, Jacobs, HK, Gopalan, AS, and Crumbliss, AL. "Synthesis and iron sequestration equilibria of novel exocyclic 3-hydroxy-2-pyridinone donor group siderophore mimics." Inorg Chem 49.18 (September 20, 2010): 8208-8221. Full Text Open Access Copy

Parker Siburt, CJ, Lin, EM, Brandt, SJ, Tinoco, AD, Valentine, AM, and Crumbliss, AL. "Redox potentials of Ti(IV) and Fe(III) complexes provide insights into titanium biodistribution mechanisms." J Inorg Biochem 104.9 (September 2010): 1006-1009. Full Text