Events

Progress towards a chemoenzymatic synthesis and antimicrobial characterization of the cyclic depsipeptide teixobactin
Speaker: 
Kelsey Morgan, graduate student
Dewey McCafferty, advisor
Friday, April 21, 2017 - 1:00pm to 2:00pm
Location: French Family Science Center 1243
Contact: 
Avery, Meg
919-660-1503

Abstract

For decades, antimicrobial chemotherapies have been a first line of defense against bacterial pathogens; however, widespread antibiotic resistance has created an urgency for the development of better therapeutics.  Teixobactin is a newly discovered antibiotic which, like several other classes of microbials, has evolved to capture the essential cell wall biosynthetic intermediate lipid II. While it is known that antibiotics that target lipid II have been largely effective, the lack of structural characterization of peptide:lipid II complexes has hindered the ability to study and understand the mechanism of lipid II recognition. Herein I describe efforts toward the development of an efficient and scalable chemoenzymatic synthesis of teixobactin, which will provide material for future efforts in characterizing the physical interactions between teixobactin and lipid II, an essential step in the development of new therapeutics.