Abstract: Recent synthetic advances have enabled the synthesis of polymers designed to elicit specific cellular functions and to direct cell-cell interactions. Motivated by traumatic injuries experienced by warfighters, we are developing novel materials and devices designed to repair segmental bone defect and achieve limb salvage. Biomimetic approaches based on polymers derivatized with adhesive receptor-binding peptides glycoproteins and tethered growth factors have been reported to enhance interactions at the biotic-synthetic interface. Further advances in both synthetic methodology and scaffold fabrication are needed to drive these efforts forward. This presentation will describe the use of several translationally relevant chemistries and functionalization strategies that are impacting the practice of medicine and how physicians are planning for future therapies that were not possible previously.